Hand-out Waters Corporation
New ZetaStar instrument for nanoparticle analysis from Wyatt Technology portfolio combines three light scattering techniques into a single device for cutting measurement time by up to 10x over other methods.
New Zeta Star™ instrument for nanoparticle analysis from Wyatt Technology™ portfolio combines three light scattering techniques into a single device – cutting measurement time by up to 10x over other methods.
Waters Corporation has unveiled its new DynaPro ZetaStar instrument, the first product released with Wyatt Technology, for nanoparticle analysis. According to its developers, the instrument enables dynamic and static light scattering (DLS and SLS) and dynamic and electrophoretic light scattering (ELS) measurements in one device. Combining multiple light scattering techniques, the automatic assessment of data quality, and the ability to perform adaptive data capture, ZetaStar can deliver increased sensitivity and faster measurements. These capabilities aid the precise development of complex biologics while using low sample volumes.
Key information:
- Waters Corporation has launched its DynaPro ZetaStar instrument for DLS, SLS, and ELS measurements.
- The launch is the first collaborative effort between Waters Corporation and Wyatt Technology.
- According to its developers, the instrument aims to boost quality assurance and speed up the measurement process.
The ZetaStar features a unique flow cell design which allows the instrument to be configured with an autosampler. Allegedly, this can drastically increase laboratory efficiency and productivity, by allowing a dozen of unattended measurements to be completed over several hours or overnight. Additionally, the instrument’s ability to measure DLS and ELS simultaneously, along with the adaptive data collection functionality, has a positive impact on the speed of traditional ELS measurements (up to 10x).
"The integration of Waters and Wyatt has reached an exciting milestone with the introduction of the ZetaStar instrument as the first new product from our combined companies," said Dr. Udit Batra, President and CEO at Waters Corporation. "Developing lipid nanoparticle-based therapies that are effective and safe hinges on light scattering technologies, like those that are built into the ZetaStar instrument. It uniquely combines three light scattering measurement techniques into a single device to provide more data points that can give biologics developers higher confidence in drug efficacy and stability."
The ZetaStar features a walk-up touchscreen interface, allowing scientists to collect five critical parameters in a single workflow. These five parameters are:
- Size.
- Polydispersity.
- Particle concentration.
- Zeta potential.
- Turbidity.
This allows for a very low sample volume (down to 2 µL). These particular parameters are fundamental when characterising the size and charge (zeta potential) of particles and macromolecules in a solution.
The instrument works by implementing a novel algorithm which can remove potential user errors and bias, this should lead to easier implementation, enabling the user to get results quicker. Additionally, system uptime has improved, which is because of the features that prevent the instrument from falling out of alignment. This also can help a lab become more efficient.
Waters Corporation believes that the ZetaStar instrument is designed to support the growing needs of biopharma formulation and development laboratories. Specifically, the instrument should help scientists who work in gene therapy, vaccines, mRNA, and proteins to develop more stable therapies. In addition, research and development laboratories could benefit from the instrument, especially during material science investigating the colloidal stability of novel molecules (e.g., quantum dots, or other metal nanoparticles used in semiconductor applications.)